Doxycycline |
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Protects against bacterial infections. Bacteria are widely distributed in the soil, water and air; parasitic bacteria live in humans, animals and plants. Sometimes bacteria cause diseases by producing poisons and toxins. Bacterial infections can be treated with antibiotics and other bactericides. The most common bacterial infections are meningitis, sinusitis, bronchitis, pneumonia, salmonella and tetanus.
| Dosage |
Packing |
Price |
Add to basket |
| 100 mg |
20 tab |
USD 17.00 |
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| 100 mg |
60 tab |
USD 43.00 |
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| 100 mg |
120 tab |
USD 79.00 |
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Medications and Prescriptions
Generic name: Doxycycline
Product Brand Name: Vibramycin ®
1. Description: Doxycycline is an antibiotic medicine belonging to the class called "tetracyclines." It is used to treat bacterial infections in many different parts of the body. It is effective against a wide variety of bacteria, such as Hemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Neisseria gonorrhoea, and many others. Doxycycline is used to treat infections and to help control acne. Doxycycline also may be used for other problems as determined by your doctor. Doxycycline will not work for colds, flu, or other virus infections.
Doxycycline is also active against the parasite that causes malaria. It is sometimes used to treat malaria, and can also be used to prevent it when visiting high-risk malarial areas, in particular areas where the malaria parasite is resistant to chloroquine.
In October 2001, FDA published a Federal Register notice clarifying that these drugs were approved for inhalational anthrax (post-exposure).
2. Doxycycline is Prescribed for: Doxycycline is used for many different types of infections, including respiratory tract infections due to Hemophilus influenzae, Streptococcus pneumoniae, or Mycoplasma pneumoniae. It also is used for the treatment of Acne vulgaris; Bubonic plague; Chlamydia; Cholera; Chronic bronchitis; Death and decay of tissue in a infected wound due to gas production by the infecting bacteria (gas gangrene); Disease caused by infection with Leptospira bacteria (Weil's Disease/leptospirosis); Disease of rodents and rabbits that can be transmitted to humans (tularaemia); Eye infections; Gonorrhoea; Infection caused by Brucella bacteria (brucellosis); Infection of the lungs and airways (chest or lower respiratory tract infection); Infections caused by Rickettsiae micro-organisms transmitted by lice, fleas, ticks and mites; Infections of the urinary tract; Infectious disease of parrots and man (parrot fever/psittacosis); Infectious disease of rodents that can be transmitted to humans (melioidosis); Inflammation of the sinuses due to infection (sinusitis); Lesions in the groin and genitalia caused by a sexually transmitted bacteria (granuloma inguinale); Louse and tick-bourne relapsing fever; Pneumonia; Prevention of an infectious disease called Scrub typhus; Prevention of infection with Leptospira bacteria (leptospirosis); Prevention of malaria; Prevention of traveller's diarrhoea (enterotoxigenic E coli); Protozoal infection of the intestine (amoebiasis); Sexually transmitted infection that causes genital ulcers (chancroid); Syphilis; Tetanus; Treatment of malaria caused by chloroquine-resistant Plasmodium falciparum.
3. Drug Mechanism: Doxycycline has been shown to inhibit collagenase activity in vitro. Additional studies have shown that doxycycline reduces the elevated collagenase activity in the gingival crevicular fluid of patients with adult periodontitis. The clinical significance of these findings is not known.
Antibacterial (systemic); antiprotozoal—Tetracyclines are broad-spectrum bacteriostatic agents that act by inhibiting protein synthesis by blocking the binding of aminoacyl-tRNA (transfer RNA) to the mRNA (messenger RNA)-ribosome complex. Reversible binding occurs primarily at the 30 S ribosomal subunit of susceptible organisms. Bacterial cell wall synthesis is not inhibited.
Diuretic (syndrome of inappropriate antidiuretic hormone [SIADH])—In the treatment of SIADH, demeclocycline acts by inhibiting ADH-induced water reabsorption in the distal portion of the convoluted tubules and collecting ducts of the kidneys, thereby causing water diuresis.
4. Dosage Form: The absorption of doxycycline is not markedly affected by food, and therefore, it can be taken with meals. For most infections, doxycycline is taken once or twice daily for 7 to 14 days. Sometimes, the first dose is given as a "double dose," that is, twice as large as the remainder of the doses.
5. Drug Interactions: Drug Interactions: It is recommended that doxycycline not be taken at the same time as aluminum-, magnesium-, or calcium- based antacids, such as Mylanta, Maalox, Tums, or Rolaids because, like food, these medications bind doxycycline in the intestine. Similarly, doxycycline should not be taken with minerals (such as calcium or iron), with bismuth subsalicylate (Pepto Bismol).
Doxycycline may enhance the activity of warfarin (Coumadin) and cause excessive "thinning" of the blood, necessitating a reduction in the dose of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism (destruction) of doxycycline thus making it less effective.
6. Pregnancy: Tetracycline antibiotics, such as doxycycline, can have toxic effects on development of bone in the fetus. Therefore, tetracyclines are not recommended during pregnancy unless there is no other appropriate antibiotic.
7. Nursing Mothers: Doxycycline is secreted into breast milk. Since tetracyclines can cause decreased bone, the use of tetracyclines in nursing mothers is of concern. The physician must decide whether to recommend that a nursing mother discontinue nursing during treatment with tetracyclines or to choose a different antibiotic.
8. Dietary and Alcohol Considerations: Avoid meats, iron-fortified cereals and iron supplements for 2 hours before and after taking this drug. Alcoholics may have reduced blood levels of doxycycline. This is because in this group of people alcohol stimulates the liver to metabolise the doxycycline. Alcohol has not been found to have this effect in people who drink moderately.
9. Possible Side Effects: Doxycycline is generally well-tolerated. The most common side effects are diarrhea or loose stools, nausea, abdominal pain, and vomiting. Tetracyclines, such as doxycycline, may cause tooth discoloration if used in persons below 8 years of age. Exaggerated sunburn can occur with tetracyclines; therefore, sunlight should be minimized during treatment.
10. Storage: Capsules should be kept below 30°C (86°F). The suspension should be refrigerated and shaken prior to each use. Talk to your pharmacist about the proper disposal of your medication. Throw away any medication that is outdated or no longer needed.
11. Package Size and Type: Capsules: 50mg, 100mg; Tablets: 100mg; Suspension: 25 mg/teaspoon; Syrup: 50 mg/teaspoon.
12. Where can I get more information?
a) U.S. National Library of Medicine and National Institutes of Health
b) WebMD Corporation
Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.
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Drug category:Antibacterial and antiviral agent
 Doxycycline
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