Zhonghua Shao Shang Za Zhi. 2001 Feb;17(1):39-41.
The effects of ecdysterone on the apoptosis and necrosis of cultured
HUVEC induced by endotoxin
Shi F, Zhang J, Zhang M.
Institute of Burn Research, Southwestern Hospital, The Third Military
Medical University, Chongqing 400038 P.R. China.
OBJECTIVE: To study the protective effects of ecdysterone (EDS)
on the apoptosis and necrosis of cultured HUVEC induced by endotoxin.
METHODS: HUVEC was cultured in vitro. Apoptosis and necrosis of
HUVEC were induced by LPS, and EDS was added in test specimen. Apoptosis
was determined by means of flow cytometry and fluorescent microscopy.
RESULTS: There was relatively less number of apoptosis and necrosis
of in vitro cultured normal HUVEC than that after LPS stimulation,
whereas apoptosis dominated over necrosis. After EDS was added to
the culture of HUVEC, cell apoptosis and necrosis decreased simultaneously.
CONCLUSION: EDS might exert protective effects on cultured HUVEC
against apoptosis and necrosis induced by LPS.
Med Parazitol (Mosk). 2002 Jan-Mar;(1):29-33.
Ecdysten in the treatment of giardiasis
Osipova SO, Islamova ZhI, Syrov VN, Badalova NS, Khushbaktova ZA.
The drug ecdisten as tablets is the natural compound ecdisteron
was extracted from Rhaponticum carthamoides (Willd.) Jljin. Ecdisten
was tested in the treatment of 32 and 3 patients with persistent
and acute giardiasis, respectively. A ten-day course of ecdisten,
5 mg 3 or 4 times a day, resulted in a clinical and parasitological
recovery in 22 (68.7%) and 3 patients, respectively. After the reuse
of a ecdisten course in 4 patients with persistent giardiasis wherein
its initial dose was increased, recovery was achieved in 3 cases,
the efficacy of the agent was 78.1%. Ecdisten should be used to
treat giardiasis, in its chronic pattern or resistance to conventional
giardicial agents.
Eksp Klin Farmakol. 1995 Sep-Oct;58(5):46-8.
A comparative study of the anabolic action of ecdysten, leveton
and Prime Plus, preparations of plant origin
Gadzhieva RM, Portugalov SN, Paniushkin VV, Kondrat'eva II.
A new class of anabolic substances includes different saponins,
originated from Leuzea rhaponticum sp. The effect of these substances
on the human body was studied by caliperometric measurements of
body folds. All tested substances taken orally for three weeks diminished
fat content under conditions of daily aerobic-anaerobic training.
Ekdisten and Prime Plus (combination of ekdisten and pure protein)
elevated the muscle mass. The same effect of leventon was less pronounced.
We showed that all substances studied elevated the magnitude of
"total work", estimated per 1 kg of body weight. Ekdisten
and Prime Plus again appeared to be most efficient. The prospects
of using the saponins in sport medicine are discussed.
Arch Insect Biochem Physiol. 1999;41(3):156-61.
20-hydroxyecdysone as a human lymphocyte and neutrophil modulator:
In vitro evaluation.
Trenin DS, Volodin VV.
The Centre of Laboratory Diagnostics, Ekaterinburg, The Institute
of Biology, Syktyvkar, Russia.
20-hydroxyecdysone (1 microM) was found to activate in vitro T-cell
CD2 presentation, which is suppressed both in secondary immunodeficient
persons and pharmacologically by increasing intracellular cAMP levels.
The compound was found to act like a synthetic psycho-immunomodulator
1-oxy-4-oxoadamantane (1 microM) and to exceed the effects of the
thymomimetic agent levamisol (1 microM). In addition, 20-hydroxyecdysone
(1 microM) was also revealed to modulate the fluoride-stimulated
respiratory burst of human neutrophils in the same manner as water
soluble antioxidants.
Ecdysten description...
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