Isoprinosine |
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Isoprinosine, also known as Imunovir has been recommended as an adjuvant treatment for cancer, age-associated immune impairments and AIDS. There have been more than 60 articles published on Isoprinosine and cancer since 1972. Isoprinosine is an immunostimulator, which besides its immunomodulatory effect also has antiviral properties. It is used in the treatment of acute and chronic viral infections. Isoprinosine acts on the immune system to restore impaired cell-mediated immune response to its baseline level, in addition to enhancing humoral immune response. The drug also has a direct antiviral activity. Isoprinosine can reduce the intensity of symptoms and shorten the duration of the viral infection. In addition, the occurrence of complications is reduced and the frequency and severity of recurrences is minimised. Isoprinosine has been found to have an immunoenhancing effect in old persons. Isoprinosine also available in SYRUP form.
Isoprinosine can also be administered for immunorestoration after chemotherapy, surgery or radiation.
| Dosage |
Packing |
Price |
Add to basket |
| 50 mg/ml sirup |
150 ml |
USD 67.00 |
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| 500 mg |
50 tab ($1.74 per tab) |
USD 87.00 |
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| 500 mg |
100 tab ($1.59 per tab) |
USD 159.00 |
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| 500 mg |
200 tab ($1.49 per tab) |
USD 298.00 |
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| 500 mg |
400 tab ($1.33 per tab) |
USD 532.00 |
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| 500 mg |
600 tab ($1.27 per tab) |
USD 762.00 |
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Isoprinosine: Medications and Prescriptions
Generic name: Inosiplex,
Product Brand Name: Isoprinosine ® (also known as Imunovir)
Product Manufacturer: Made in Switzerland, license from Newport Pharm.
Isoprinosine description
Isoprinosine is an immunomodulator and is approved for immunorestoration in chemotherapy in some countries. Patients on chemotherapy are particularly susceptible to different viral infections as a result of chemotherapy-induced immunodepression. Adjuvant therapy with Isoprinosine can restore the cell-mediated immune response to the individual's baseline levels.
It can therefore be prescribed during chemotherapy to restore the immune response and as a prophylaxis against reactivation of latent herpes simplex or herpes varicelliform zoster (shingles) infections, or for treatment or management of other secondary viral infections.
In these instances, the dosage used is the standard 50 mg/kg/day of lean body weight, up to a maximum of 3g daily (6x 500 mg tablets), divided evenly during waking hours. Schedule of treatment depends on the type of chemotherapeutic agent used. Isoprinosine is only administered after the infusion and only when the desired immune suppression against the cancerous cells has taken effect. At that point between infusions when it is desirable for the immune system to normalise, Isoprinosine treatment is initiated in order to enhance the normal immune response recovery. The number of treatment days depends on the length of time between infusions and also the immune profile of the individual patient.
Isoprinosine can also be administered for immunorestoration after chemotherapy, surgery or radiation.
Prescribing information, recommended dosage:
The prescribing physician will ultimately decide about the details of therapy (dosing, duration, etc.). According to dosing information obtained from published references; patients with cancer can take 2000 mg to 3000 mg of Isoprinosine daily for two months (4-6 tabs of 500 mg Isoprinosine per day). Then they may stop taking Isoprinosine for two months, and then resume taking it at the same dose for another two months.
How Does Isoprinosine work?
Isoprinosine is a synthetic purine derivative with immunomodulatory and antiviral properties, which result from an apparent in vivo enhancement of host immune responses due to the drug.
The action of Isoprinosine can be summarized as follows:
--- Normalizes the cell-mediated immunity by stimulating the differentiation of T-lymphocytes into T-cytotoxic cells and T-helper cells and increasing lymphokine production
--- Increases production of IL-1 (interleukin-1) and IL-2 (interleukin-2) and IFN-? (gamma interferon)
--- Increases NK cell (natural killer cell) function
--- Increases the humoral immune response by stimulating the differentiation of B- lymphocytes into plasma cells and by enhancing antibody production
--- Increases the number of IgG and complement surface markers
--- Potentiates neutrophil, monocyte and macrophage chemotaxis and phagocytosis
--- Inhibits viral growth by suppressing viral RNA synthesis while potentiating depressed lympocytic
--- RNA synthesis and translational ability
Other benefits of Isoprinosine treatment: Studies have documented the ability of Isoprinosine to slow the progression of AIDS in HIV-infected persons by increasing the total number and activity of T-cells, T-helper cells and NK (natural killer) cells. The largest study, which was published in The New England Journal of Medicine on June 21, 1990 found that HIV infected people with CD4 cells count over 500 experienced significant benefits from Isoprinosine therapy. T-lymphocyte defects are common in cancer and AIDS patients according to a study in Medical Oncological Tumor Pharmacotherapy in 1989, which found that Isoprinosine and levamisole (another immune-boosting drug) mimic the actions of the thymic hormones to promote T-cell development. Combinations of Isoprinosine, low-dose Interleukin 1 and 2, and other immune-modulating hormones such as Melatonin are suggested as possibly effective cancer therapies.
Packing:
50 tablets, 500 mg
150 ml syrop, 50 mg/ml
Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.
Isoprinosine Could Help in Chronic Fatigue Syndrome (ME/CFS) Doctors Report: In 1999 Dr. Byron Hyde reported that a small Isoprinosine study was 'milestone' in the treatment of ME/CFS. Dr. Paul Cheney calls Isoprinosine a 'very good immune-modulator' and appears to have used it extensively to boost NK cell functioning and reduce Th2 dominance in the immune system. In 2007 Dr. De Meirleir stated that he felt that Inosine - an amino acid available in health food stores - was as effective as Isoprinosine.
Chronic Fatigue Syndrome (ME/CFS) studies - Few studies have assessed Isoprinosine's effectiveness in ME/CFS. After a small single blind, placebo-controlled trial of 16 patients in 1999 Dr.Hyde's published study (2003) indicated that 6/10 patients improved and that their natural killer cell activity and T-helper cell numbers increased but no changes were seen in IFN-y, IL-1@, IL-10 and IL-12 levels. At the 2009 IACFS/ME conference Dr. Hone reported that Isoprinsine conferred 'significant (clinical)improvement' and increased NK cell functioning and reduced Epstein-Barr Virus levels in patients with reduced natural killer cell activity.
Dosages:
Because of its immunomodulatory properties Dr. Cheney recommends staggering dosages:
First Month:
•Week One: 6 tablets a day (M-F)
•Week Two: 2 tables a day (M-F)
•Week Three: Repeat Week One
•Week Three: Repeat Week Two
Second Month: Repeat first month
Third Month: Stop Isoprinosine
Four Month: Repeat Month 1
Fifth Month: Repeat Month 1
Six Month: Stop Isopoprinosine
Isoprinosine Syrup
A clear viscous oral solution with a mirabelle plum aroma.
Dosage is determined on the basis of lean body weight of the patient and the severity of the disease. Daily administration should be divided evenly during waking hours. The normal duration of acute treatment is 5-14 days.
Adults and the Elderly:
50mg/kg of body weight daily, up to a maximum of 4g, (usually, 20ml x 3-4 times a day).
Children over the age of 1 year:
50mg/kg of body weight daily, (10ml per 10 kg up to 20kgs; thereafter, use adult dose).
SSPE Dosage:
100mg/kg of body weight daily, up to a maximum of 3-4g, continuously, with regular monitoring to evaluate patient status and requirement for extended treatment.
Genital Warts Dosage:
3g (20ml x 3 times a day) for a total of 14-28 days, as an adjunct to conventional topical or surgical procedures
Clinical trial results:
http://www.rivexpharma.com/pdf/Imunovir_study.pdf
Isoprinosine notes:
Isoprinosine having generic name Inosiplex (or Immunovir) is an old drug that has been extensively used for herpes, genital warts, influenza, melanomas, other tumors, hepatitis B, a rare brain inflammation in children caused by the zoster virus (subacute sclerosing panencephalitis) and cancer.
This medication is approved in Canada and many other countries as an anti-viral drug. It is also used to treat chronic fatigue syndrome called as fibromyalgia.
According to a clinical study, Isoprinosine was successfully used to treat viral infections in patients with acute leukemia, chronic leukemia and Hodgkin’s disease. It was also used to evaluate the immune function in cancer patients receiving pelvic radiation. Many studies have published indicating Isoprinosine’s antiviral and immunostimulatory effects benefiting AIDS patients.
Isoprinosine is reported to have fewer side effects. Some of them are dizziness, stomach pain, digestion problem and itching. When this medication is given with ribavarin it causes drop in the white blood cells count of patient. Intake of Isoprinosine may results in certain allergic reactions like tightness in the chest or throat, skin hives, rashes, chest pain and itchy skin.
The recommended dosage of Isoprinosine is as prescribed by doctor. Generally it is taken as 1 – 4 gms per day i.e. 2 – 8 tablets per day. Isoprinosine is available in 500 mg tablets form. This medication can also be given as syrup. The price of Isoprinosine syrup for 150ml package is USD 67.
Consult doctor before taking this medication if you are pregnant or planning to become pregnant during the treatment. Physician's advice is necessary for lactating women if taking Isoprinosine. This medicine should not be taken by children.
Store Isoprinosine in a dry and cool place within a tight container.
Life-extension news:
Fatty food responsible for weak immune system – A thesis
According to a thesis from Sahlgrenska Academy the intake of fatty food can worsen the fighting capacdity of immune system. The trial was carried out on mice who were fed for a long duration of time, a lard-based diet derived 60 per cent of their total calories from fat. These mice were compared with other mice that were fed a low-fat diet where no more than ten per cent of their calories came from fat and as expected the mice on the high-fat diet shows increased obesity.
The researchers were surprised when they notice that the immune system in the mice with high fat diet was less active and that the white blood cells got worse at dealing with bacteria in the blood which could have contributed to many dying of sepsis.
Doctoral student louise strandberg said that obesity is usually associated with inflammation that does not result from an infection, which simply means that the immune defences are activated unnecessarily but in this study the case has reverse as the immune system has decreases in the mice when they really need it. Similarly fat people are also at a greater risk of acquiring infection. It is clear from the trial that fatty food is responsible rather than obesity in itself which affects the ability to fight off sepsis caused by bacteria.
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Drug category:Immunostimulators
 Isoprinosine
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