Pantocrin scientific update |
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Radiobiologiia. 1990 Mar-Apr;30(2):170-4.
Narimanov AA, Kuznetsova SM, Miakisheva SN.
The modifying action of the Japanese pagoda tree (Sophora japonica) and pantocrine in radiation lesions
A study was made of the effect of Sophora japonica and pantocrine on irradiated (2.5 Gy) human lymphoblastoid cells. The radioprotective effect was manifested with the preparations injected separately after irradiation. The highest radioprotective effect was produced by the mixture of the preparations, the injection 15 min after irradiation being more effective than preinjection. The protective effect of the agents was studied on mongrel mice after the administration thereof for the purposes of protection protection-and-treatment and treatment. Sophora japonica and pantocrine were shown to increase the survival rate of lethally exposed mice (LD90/30) when administered in a combination 5-15 min before irradiation and when used for the purposes of protection--and--treatment: 53.3% and 50% of animals, respectively, survived by day 30 following irradiation. DMF was 1.25.
Eksp Klin Farmakol. 2001 Nov-Dec;64(6):60-2.
Kropotov AV, Lisakovskaia OV, Khotimchenko IuS.
Pharmacology Department, Vladivostok State Medical University, Prospekt Ostryakova 2, Vladivostok, 690002 Russia.
Seasonal features of the effect of adaptogens on sex behavior of experimental animals
Seasonal variation of the aphrodiatical activity of pantocrin (deer antler extract), ginseng root tincture, and eleuterococcus extract was studied. It was found that a one-month treatment with these adaptogen preparations in a daily dose of 100 mg/kg (for dry parent substance) stimulate the sexual behavior of puberal mice and rat males in winter. The maximum effect was observed for pantocrin. In summer months, the stimulating effect of adaptogens was not manifested. The reference drug (tentex forte) increased the sexual behavior irrespective of the season, the effect being more pronounced in summer months. These results are explained by assuming that the adaptogens studied possess a weak gonadotropic activity, which favors normalization of the testosterone level (reduced in winter season) in experimental animals.
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 Pantocrin scientific update
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