Vinpocetine |
|
 |
|
Vinpocetine is a preventive anti-stroke remedy.
It also enhances circulation in the brain, and improves memory and hearing abilities. Arteriosclerosis progression in brain is retarded.
ginkgo biloba vinpocetine, ginkgo vinpocetine, biloba vinpocetine, ginkgo biloba with vinpocetine, vinpocetine benefits, vinpocetine blood pressure, vinpocetine autism, intelectol reviews, intelectol side effects, cavinton forte, cavintone vinpocetine.
| Dosage |
Packing |
Price |
Add to basket |
| 5 mg |
50 tab ($0.20 per tab) |
USD 10.00 |
 |
| 5 mg |
100 tab ($0.17 per tab) |
USD 17.00 |
|
| 5 mg |
200 tab ($0.15 per tab) |
USD 30.00 |
|
| 10 mg |
30 tab ($0.40 per tab) |
USD 12.00 |
|
| 10 mg |
90 tab ($0.33 per tab) |
USD 30.00 |
|
| 10 mg |
180 tab ($0.25 per tab) |
USD 45.00 |
|
Vinpocetine: Medications and Prescriptions
Product Brand Name: Vinpocetine, Cavinton, Intelectol
Vinpocetine description
DESCRIPTION:
Vinpocetine is a semi-synthetic derivative of vincamine. Vincamine is an alkaloid derived from the plant Vinca minor L., a member of the periwinkle family. Vinpocetine, as well as vincamine, are used in Europe, Japan and Mexico as pharmaceutical agents for the treatment of cerebrovascular and cognitive disorders. In the United States, vinpocetine is marketed as a dietary supplement. It is sometimes called a nootropic, meaning cognition enhancer, from the Greek noos for mind.
Vinpocetine is also known as ethyl apovincaminate; ethyl apovincaminoate; eburnamenine-14-carboxylic acid ethyl ester; 3 alpha, 16 alpha-apovincaminic acid ethyl ester; ethyl apovincamin-22-oate; and cavinton, which is sometimes used generically for a branded product with that name. Another vinca alkaloid called vinconate is also being researched as a possible cognition enhancer. The structural formula of vinpocetine is:
PHARMACOLOGY:
Vinpocetine has several possible actions, including increasing cerebral blood flow and metabolism, anticonvulsant, cognition enhancement, neuroprotection and antioxidant. Vincamine, the parent compound of vinpocetine, is believed to be a cerebral vasodilator.
MECHANISM OF ACTION:
Several mechanisms have been proposed for the possible actions of vinpocetine. Vinpocetine has been reported to have calcium-channel blocking activity, as well as voltage-gated sodium channel blocking activity. It has also been reported to inhibit the acetylcholine release evoked by excitatory amino acids and to protect neurons against excitotoxicity. In addition, vinpocetine has been shown to inhibit a cyclic GMP phosphodiesterase, and it is speculated that this inhibition enhances cyclic GMP levels in the vascular smooth muscle, leading to reduced resistance of cerebral vessels and increase of cerebral flow. In some studies, vinpocetine has demonstrated antioxidant activity equivalent to that of vitamin E.
PHARMACOKINETICS:
Vinpocetine is absorbed from the small intestine, from whence it is transported to the liver via the portal circulation. From the liver via the systemic circulation, it is distributed to various tissues in the body, including the brain. Absorption of vinpocetine is significantly higher when given with food and can be up to about 60% of an ingested dose. On an empty stomach, absorption of an ingested dose can be as low as 7%. Peak plasma levels are obtained one to one and a half hours after ingestion. Extensive metabolism to the inactive apovincaminic acid occurs in the liver. Only small amounts of unmetabolized vinpocetine are excreted in the urine, the major route of excretion of apovincaminic acid. Most of a dose is excreted within 24 hours as this metabolite. The elimination half-life of vinpocetine following ingestion is one to two hours.
INDICATIONS AND USAGE:
The primary claim made for vinpocetine is that it decreases fatality and dependency in ischemic stroke. Research results are mixed. Vinpocetine has not been helpful in Alzheimer's disease, but there is some suggestion that it might help some with other dementias and cerebral dysfunction. Very preliminary research additionally suggests that vinpocetine may help protect the eye and ear from injuries caused by trauma (and, in the case of the eye, from infection) and that it might be gastroprotective, ameliorate symptoms of motion sickness and help prevent atherosclerosis.
Dosage:
5 mg, 10 mg
3-4 tablet daily
RESEARCH SUMMARY:
Several small studies, in both animals and humans, have reported significant vinpocetine-associated protective effects in ischemic stroke. A review of these studies, however, found only one positive study of a truly randomized, unconfounded clinical trials that compared the effect of vinpocetine to either placebo or another reference treatment for acute stroke where treatment started no later than 14 days after stroke onset. There is currently not enough evidence to determine whether vinpocetine does or does not reduce fatalities and dependence in ischemic stroke. Further research is needed.
There is some evidence vinpocetine may be useful in some other cerebral maladies. In one multi-center, double-blind, placebo-controlled study lasting 16 weeks, 203 patients described as having mild to moderate psychosyndromes, including primary dementia, were treated with varying doses of vinpocetine or placebo. Significant improvement was achieved in the vinpocetine-treated group as measured by "global improvement" and cognitive performance scales. Three 10-milligram doses daily were as effective or more effective than three 20-milligram doses daily. Similarly good results were found in another double-blind clinical trial testing vinpocetine versus placebo in elderly patients with cerebrovascular and central nervous system degenerative disorders. Studies of Alzheimer's disease, however, have shown no vinpocetine benefit.
Some preliminary research suggests that vinpocetine may have some protective effects in both sight and hearing. One study of patients with mild burn trauma in the eyes showed that vinpocetine enhanced healing, most likely as a result of increased blood flow to the damaged tissue. Vinpocetine has also been associated with improvements seen in retinas damaged by hepatitis B virus. Damage from acoustic trauma has similarly been reduced by vinpocetine treatment.
Vinpocetine gastroprotective effects have been reported in animal models challenged with noxious agents. There are anecdotal reports that vinpocetine is protective against some of the gastric and neurological toxicity of excessive alcohol consumption.
There are some reports that vinpocetine may be an effective motion sickness preventative and some early findings in animals that it may exert some anti-atherosclerotic effects through a reported ability to decalcify cholesterol-induced atherosclerotic lesions.
CONTRAINDICATIONS:
None known.
PRECAUTIONS:
Pregnant women and nursing mothers should avoid vinpocetine supplements. Those with a history of allergic reactions or hypersensitivity reactions during treatment with other vinca alkaloids, such as vinblastine and vincristine, should avoid vinpocetine. Those on warfarin are advised to have their INRs (international normalized ratios) regularly monitored when using vinpocetine supplements (see Interactions). Those with hypotension or orthostatic hypotension should be cautioned that prolonged use of vinpocetine may lead to slight reductions in systolic and diastolic blood pressure.
ADVERSE REACTIONS:
Reported adverse reactions include nausea, dizziness, insomnia, drowsiness, dry mouth, transient hypotension, transient tachycardia, pressure-type headache and facial flushing. Slight reductions in both systolic and diastolic blood pressure with prolonged use of vinpocetine have been reported, as well as slight reductions in blood glucose.
INTERACTIONS:
Warfarin—Slight changes in prothrombin time have been noted in those adding vinpocetine to warfarin dosing. The changes appear minimal. However, regular monitoring of INR is advised in those using warfarin and vinpocetine concomitantly. There are no other known drug or nutritional supplement, herb or food interactions.
OVERDOSAGE:
There are no reports of vinpocetine overdosage.
DOSAGE AND ADMINISTRATION:
Vinpocetine is available as an individual supplement and in combination products. Typical doses for supplement use are 5 to 10 milligrams daily with food. Some take up to 20 milligrams daily. Higher doses are not advised.
Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.
Vinpocetine notes:
Vinpocetine also known as ethyl apovincaminate is use for the treatment of cerebrovascular and cognitive disorders. The possible actions of Vinpocetine include increasing cerebral blood flow and metabolism, anticonvulsant, cognition enhancement, neuroprotection and antioxidant.
Ginkgo Biloba with Vinpocetine helps in increasing blood circulation in brain, memory, attention and focus. The combination also increases the brain cells abilities to absorb the additional nutrients.
Vinpocetine benefits in cerebral circulation and decreased platelet aggregation by inhibiting calcium calmodulin-dependent phosphodiesterase which leads to increase in cyclic adenosine monophosphate.
Side effects of Vinpocetine include indigestion, nausea, dizziness, anxiety, facial flushing, insomnia, headache, drowsiness and dry mouth. It should not be taken by pregnant or nursing women. People with bleeding disorders, seizure disorders or low blood pressure shouldn't take Vinpocetine.
Cavinton Forte is the product brand name for Vinpocetine which is use as cure for preventive anti-stroke condition. It also helps to improve the blood circulation in the brain, and develop the memory power of as well as the hearing abilities.
Vinpocetine is use in treatment of autism, sclerosis and Alzheimer.
Intelectol is the one of the forms of Vinpocetine available. It is a memory pill, a dietary supplement which enhances memory power. There are no known side effects of Intelectol.
There are no as such intelectol reviews available, it is recommended to research deeply and then go for this product. It is recommended that first-time users ingest only 2-5 mg of Vinpocetine with meals to make sure they are not hypersensitive to it.
Cavinton (vinpocetine) has proved to be a successful drug in the treatment of many acute and chronic disorders related to the functioning of the brain which includes transient ischemia, progressing strokes and even the post stroke conditions.
Store it in a cool dry place away from direct light.
Life-extension news:
Exercise improves IQ in young adults – says study
According to the latest study carried out at the Sahlgrenska Academy and Sahlgrenska University Hospital had revealed that regular exercise by young adults improves their IQ. In this study, 1.2 million men were enrolled who were both between 1950 and 1976. The physical test and IQ analysis was done for men who were enroll for this study. The results clearly indicates the link between increased physical fitness and IQ improvement which mainly includes logical thinking and verbal comprehension.
Michael Nilsson, professor at the Sahlgrenska Academy and chief physician at the Sahlgrenska University Hospital said that being physically fit means to have good heart and lung capacity and that brain gets plenty of oxygen which may be the reason for clear link with fitness. Maria Åberg, researcher at the Sahlgrenska Academy added that youngsters who improve their physical fitness between the ages of 15 and 18 shows the considerable increase in their cognitive performance.
The link between physical fitness and mental performance has also previously been demonstrated in studies carried out on animals, children and old people. However, studies on young adults have been contradictory to all previous studies. It is possible that around the age of twenty brain may still change rapidly as a result of both cognitive and emotional development.
Anti-Aging News:
Ginkgo Biloba not useful to keep sharp mind in old age – says study
According to the latest study conducted by University of Virginia School of Medicine in Charlottesville, consumption of ginkgo biloba drug which is said to keep mind sharp at older age doesn't restrict the cognition decline. Ginkgo biloba is believed to have antioxidant and anti-inflammatory properties that protect cell membranes and help govern the workings of the brain's chemical messengers or neurotransmitters.
Lead researcher Dr. Steven T. DeKosky said that measuring the effect of ginkgo in a big trial in older people doesn't show any effect of the drug on slowing down or delaying normal age-related changes of cognition. To test the effect of this drug, statistics were created derived from the results of ginkgo Evaluation of Memory study, which included 3,069 community-dwelling adults age ranging from 72 to 96 years. The participants initially took 120 milligrams of ginkgo or placebo twice a day and were routinely tested for cognitive abilities. Over more than six years of follow-up, the researchers found no evidence that ginkgo delayed or prevented normal declines in memory, language, attention, visuospatial abilities or executive functions such as anticipating outcomes and adapting to changing situations and thinking abstractly.
Researchers added that gingko was fairly safe but it didn't seem to do anything to slow down the cognitive changes of aging. Earlier results from the same study had found that ginkgo did not prevent or slow the development of Alzheimer's. But there is a large body of previously published evidence which suggests that ginkgo biloba is effective for improving cognitive impairment in older adults.
|
|
Drug category:Nootropic and smart drugs
 Vinpocetine
Buy here
|
|
My Basket